开放蠕虫

开放蠕虫（OpenWorm）是一项旨在从细胞层面在电脑上模拟秀丽隐杆线虫（Caenorhabditis elegans）的国际性开放科学项目。[1] [2][3]尽管该项目的长远目标是模拟整个秀丽隐杆线虫的全部959个细胞，第一阶段的计划是建立包含302个神经元和95个肌肉细胞的模型来模拟蠕虫运动。这种自底向上的模拟是开放蠕虫社区追求的目标。目前，此项目的物理引擎Sibernetic已经建好，神经连接组和肌肉细胞也已创建为NeuroML格式。整个蠕虫的三维解剖模型可以通过浏览器自由查看。开放蠕虫项目也参与了“Geppetto模拟框架”的开发，这是一个为开发有机体的整体建模而创设的多重算法、多尺度的模拟平台。[4]

参考文献
  1. nematode fanciers open their worm to a kickstarter
  2. Towards a virtual C. elegans: A framework for simulation and visualization of the neuromuscular system in a 3D physical environment. Palyanov A., Khayrulin S., Larson S.D. and Dibert A. (2012) In Silico Biology 11(3): 137-147
  3. Current practice in software development for computational neuroscience and how to improve it. Gewaltig, M.-O., & Cannon, R. (2014). PLoS Computational Biology, 10(1), e1003376. doi:10.1371/journal.pcbi.1003376
  4. Openworm is going to be a digital organism in your browser

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