炔诺酮

**炔诺酮**
系统（IUPAC）命名名称
	(8R,9S,10R,13S,14S,17R)-17-ethynyl-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
临床数据
商品名	Alone: Aygestin, Camila, Heather, Micronor, Primolut N, others; With EE: Lo Loestrin, Loestrin, Microgestin, Modicon, Norinyl, Ortho-Novum, others; With E2: Activella, Activelle, Estalis, Kliogest, Necon, Novofem, Trisequens, others
Drugs.com	国际药品名称
MedlinePlus	a604034
给药途径	By mouth, intramuscular injection (as NETE)
药代动力学数据
生物利用度	47–73% (mean 64%)[1][2]
蛋白结合度	97%:; Albumin: 61%;; SHBG: 36%
代谢	Mainly CYP3A4 (liver);[3] also 5α-/5β-reductase, 3α-/3β-HSD, and aromatase
生物半衰期	5.2–12.8 hours (mean 8.0 hours)[1]
识别
CAS注册号	68-22-4
ATC代码	G03AC01 G03DC02
PubChem	CID 6230
IUPHAR/BPS	2880
DrugBank	DB00717
ChemSpider	5994
UNII	T18F433X4S
KEGG	D00182
ChEBI	CHEBI:7627
ChEMBL	CHEMBL1162
其他名称	NET; Norethindrone; NSC-9564; LG-202; Ethinylnortestosterone; Norpregneninolone; Anhydrohydroxy-norprogesterone; Ethinylestrenolone; 17α-Ethynyl-19-nortestosterone; 17α-Ethynylestra-4-en-17β-ol-3-one; 17α-Hydroxy-19-norpregn-4-en-20-yn-3-one
化学
化学式	C20H26O2
摩尔质量	298.419 g/mol
	SMILES C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=CC(=O)CC[C@H]34;
	InChI InChI=1S/C20H26O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,12,15-18,22H,4-11H2,2H3/t15-,16+,17+,18-,19-,20-/m0/s1 ; Key:VIKNJXKGJWUCNN-XGXHKTLJSA-N ;
物理性质
熔点	203至204 °C（397至399 °F）

炔诺酮（英語：或英語：）是一种黄体制剂药物，用做口服避孕药和激素替代療法药物以及治疗一些妇科疾病[4]。

参考文献

Stanczyk, Frank Z. (PDF). Reviews in Endocrine and Metabolic Disorders. Sep 2002, 3 (3): 211–224. ISSN 1389-9155. PMID 12215716. doi:10.1023/A:1020072325818.
Fotherby K. . Contraception. August 1996, 54 (2): 59–69. PMID 8842581. doi:10.1016/0010-7824(96)00136-9.
Korhonen T, Turpeinen M, Tolonen A, Laine K, Pelkonen O. . J. Steroid Biochem. Mol. Biol. 2008, 110 (1–2): 56–66. PMID 18356043. doi:10.1016/j.jsbmb.2007.09.025.
Kathryn Rhodes Alden; Deitra Leonard Lowdermilk; Mary Catherine Cashion; Shannon E. Perry. . Elsevier Health Sciences. 27 December 2013: 135–. ISBN 978-0-323-29368-6.

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[pmid12215716-1] Stanczyk, Frank Z. (PDF). Reviews in Endocrine and Metabolic Disorders. Sep 2002, 3 (3): 211–224. ISSN 1389-9155. PMID 12215716. doi:10.1023/A:1020072325818.

[pmid8842581-2] Fotherby K. . Contraception. August 1996, 54 (2): 59–69. PMID 8842581. doi:10.1016/0010-7824(96)00136-9.

[pmid18356043-3] Korhonen T, Turpeinen M, Tolonen A, Laine K, Pelkonen O. . J. Steroid Biochem. Mol. Biol. 2008, 110 (1–2): 56–66. PMID 18356043. doi:10.1016/j.jsbmb.2007.09.025.

[AldenLowdermilk2013-4] Kathryn Rhodes Alden; Deitra Leonard Lowdermilk; Mary Catherine Cashion; Shannon E. Perry. . Elsevier Health Sciences. 27 December 2013: 135–. ISBN 978-0-323-29368-6.