类固醇生成因子1

類固醇生成因子
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1YOW、1ZDT、4QJR、4QK4
識別號
别名	NR5A1；, AD4BP, ELP, FTZ1, FTZF1, POF7, SF-1, SF1, SPGF8, SRXY3, hSF-1, nuclear receptor subfamily 5 group A member 1, SRXX4
外部ID	OMIM：184757 MGI：1346833 HomoloGene：3638 GeneCards：NR5A1
基因位置（人类）
染色体	染色体9（人类）[1]
终止	124,507,420 bp[1]
基因位置（小鼠）
染色体	染色体2（小鼠）[2]
终止	38,714,542 bp[2]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• 血浆蛋白结合; • 鋅離子結合; • lipid binding; • double-stranded DNA binding; • 酶结合; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • steroid hormone receptor activity; • 转录共激活因子活性; • phospholipid binding; • 金屬離子結合; • DNA结合转录因子活性; • RNA polymerase II cis-regulatory region sequence-specific DNA binding; • DNA结合; • chromatin binding; • RNA polymerase II regulatory region sequence-specific DNA binding; • nuclear receptor activity; • sequence-specific DNA binding; • DNA-binding transcription factor activity, RNA polymerase II-specific; • transcription regulatory region sequence-specific DNA binding;
細胞組分	• 核质; • RNA polymerase II transcription factor complex; • 细胞核;
生物學過程	• regulation of transcription from RNA polymerase II promoter; • positive regulation of transcription, DNA-templated; • regulation of steroid biosynthetic process; • hormone metabolic process; • luteinization; • reproductive process; • primary sex determination; • 组织发生; • multicellular organism aging; • 细胞分化; • maintenance of protein location in nucleus; • regulation of transcription, DNA-templated; • adrenal gland development; • transcription, DNA-templated; • steroid hormone mediated signaling pathway; • cell-cell signaling; • transcription from RNA polymerase II promoter; • negative regulation of female gonad development; • transcription initiation from RNA polymerase II promoter; • positive regulation of male gonad development; • intracellular receptor signaling pathway; • positive regulation of transcription from RNA polymerase II promoter; • sex determination; • male gonad development; • female gonad development; • positive regulation of gene expression; • hormone-mediated signaling pathway; • calcineurin-mediated signaling; • response to gonadotropin-releasing hormone; • male sex determination;
	Sources:Amigo / QuickGO
直系同源
	2516
	26423
	ENSG00000136931
	ENSMUSG00000026751
	Q13285
	P33242
	NM_004959
	NM_139051、NM_001316687
	NP_004950; NP_004950.2、XP_005251928.1、XP_011516757.1
	NP_001303616、NP_620639
	維基數據

类固醇生成因子1（英語：，缩写SF-1）是一种参与性別決定的转录因子，涉及生殖腺与肾上腺[5]。这一蛋白由NR5A1基因编码，属于核受体超家族，位于9号染色体长臂段的位置33.3。SF-1最初发现于其能调节CYP450类固醇羟化酶的表达，因而得名，之后又发现了参与调控许多相关基因[6]。

目标基因

类固醇生成细胞

SF-1最早在肾上腺皮质的类固醇生成细胞中被鉴定出具有调控类固醇生成酶活性，此后又发现在其它类固醇生成细胞中的活性[6]：

表 1. SF-1 在类固醇生成细胞中的目标基因
物种	基因	细胞/组织	来源
大鼠	CYP11A1	颗粒细胞	[7]
小鼠	CYP11A1	Y1肾上腺皮质细胞	[8]
牛	催产素	卵巢	[9]
小鼠	StAR	MA-10细胞	[10]

参考文献

GRCh38: Ensembl release 89: ENSG00000136931 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026751 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
Reference, Genetics Home. . Genetics Home Reference. [2017-11-30] （英语）.
Parker KL, Schimmer BP. . Endocrine Reviews. June 1997, 18 (3): 361–77. PMID 9183568. doi:10.1210/edrv.18.3.0301.
J W Clemens, D S Lala, K L Parker, J S Richards. . Endocrinology. 1994-03, 134 (3): 1499–1508 [2020-02-02]. ISSN 0013-7227. doi:10.1210/endo.134.3.8119192 （英语）.
R.J. Ferrier. . Carbohydrate Research. 1990-07, 202: ix–xi [2020-02-02]. doi:10.1016/0008-6215(90)84066-4 （英语）.
U. Wehrenberg, R. Ivell, M. Jansen, S. von Goedecke, N. Walther. . Proceedings of the National Academy of Sciences. 1994-02-15, 91 (4): 1440–1444 [2020-02-02]. ISSN 0027-8424. PMC 43175. PMID 8108428. doi:10.1073/pnas.91.4.1440 （英语）. 引文格式1维护：PMC格式 (link)
K. M. Caron. . Molecular Endocrinology. 1997-02-01, 11 (2): 138–147 [2020-02-02]. ISSN 0888-8809. doi:10.1210/me.11.2.138 （英语）.

外部链接

GeneReviews/NCBI/NIH/UW entry on 46,XY Disorder of Sex Development and 46,XY Complete Gonadal Dysgenesis
OMIM entries on 46,XY Disorder of Sex Development and 46,XY Complete Gonadal Dysgenesis
MeSH（醫學主題詞）上面的steroidogenic+factor+1（美式英语）

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000136931 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026751 - Ensembl, May 2017

[3] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Reference, Genetics Home. . Genetics Home Reference. [2017-11-30] （英语）.

[Parker_1997-6] Parker KL, Schimmer BP. . Endocrine Reviews. June 1997, 18 (3): 361–77. PMID 9183568. doi:10.1210/edrv.18.3.0301.

[7] J W Clemens, D S Lala, K L Parker, J S Richards. . Endocrinology. 1994-03, 134 (3): 1499–1508 [2020-02-02]. ISSN 0013-7227. doi:10.1210/endo.134.3.8119192 （英语）.

[8] R.J. Ferrier. . Carbohydrate Research. 1990-07, 202: ix–xi [2020-02-02]. doi:10.1016/0008-6215(90)84066-4 （英语）.

[9] U. Wehrenberg, R. Ivell, M. Jansen, S. von Goedecke, N. Walther. . Proceedings of the National Academy of Sciences. 1994-02-15, 91 (4): 1440–1444 [2020-02-02]. ISSN 0027-8424. PMC 43175. PMID 8108428. doi:10.1073/pnas.91.4.1440 （英语）. 引文格式1维护：PMC格式 (link)

[10] K. M. Caron. . Molecular Endocrinology. 1997-02-01, 11 (2): 138–147 [2020-02-02]. ISSN 0888-8809. doi:10.1210/me.11.2.138 （英语）.