LAMA1

LAMA1
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	2JD4
識別號
别名	LAMA1；, LAMA, S-LAM-alpha, PTBHS, Laminin, alpha 1, laminin subunit alpha 1
外部ID	OMIM：150320 MGI：99892 HomoloGene：21146 GeneCards：LAMA1
相關疾病
	2型糖尿病、ataxia-intellectual disability-oculomotor apraxia-cerebellar cysts syndrome[1]
基因位置（人类）
染色体	18號染色體[2]
终止	7,117,797 bp[2]
基因位置（小鼠）
染色体	小鼠17号染色体[3]
终止	67,822,647 bp[3]
RNA表达模式
	; ;
	查阅更多表达数据
基因本體
分子功能	• receptor binding; • extracellular matrix structural constituent; • 血浆蛋白结合; • protein C-terminus binding; • glycosphingolipid binding;
細胞組分	• 细胞外间质; • 細胞外區域; • 基底膜; • laminin-1 complex; • laminin-3 complex; • 細胞外空間; • 膜; • intercellular junction; • laminin complex; • collagen-containing extracellular matrix;
生物學過程	• cell surface receptor signaling pathway; • regulation of cell adhesion; • 細胞粘附; • extracellular matrix organization; • regulation of cell migration; • regulation of embryonic development; • morphogenesis of an epithelial sheet; • protein phosphorylation; • 组织发生; • neuron projection development; • establishment of epithelial cell apical/basal polarity; • retina development in camera-type eye; • epithelial tube branching involved in lung morphogenesis; • branching involved in salivary gland morphogenesis; • retinal blood vessel morphogenesis; • 轴突导向; • animal organ morphogenesis; • camera-type eye development; • blood vessel morphogenesis;
	Sources:Amigo / QuickGO
直系同源
	284217
	16772
	ENSG00000101680
	ENSMUSG00000032796
	P25391
	P19137
	NM_005559
	NM_008480
	NP_005550
	NP_032506
	維基數據

层粘连蛋白亚基α1是一个层粘连蛋白的蛋白亚基。层粘蛋白是一种组成核纤层的蛋白，在细胞核的形态维持中扮演重要角色。此蛋白質在人体内由LAMA1基因编码[6][7]。

相互作用

层粘蛋白亚基α1会与FBLN2发生蛋白质相互作用[8][9]。

参考资料

.
GRCh38: Ensembl release 89: ENSG00000101680 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000032796 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
Nagayoshi T, Mattei MG, Passage E, Knowlton R, Chu ML, Uitto J. . Genomics. 1990-01, 5 (4): 932–5. PMID 2591971. doi:10.1016/0888-7543(89)90136-5.
.
Utani, A; Nomizu M; Yamada Y. . J. Biol. Chem. (UNITED STATES). 1997-01, 272 (5): 2814–20. ISSN 0021-9258. PMID 9006922. doi:10.1074/jbc.272.5.2814.
Talts, J F; Sasaki T; Miosge N; G?0?2hring W; Mann K; Mayne R; Timpl R. . J. Biol. Chem. (UNITED STATES). 2000-11, 275 (45): 35192–9. ISSN 0021-9258. PMID 10934193. doi:10.1074/jbc.M003261200.

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[1] .

[refGRCh38Ensembl-2] GRCh38: Ensembl release 89: ENSG00000101680 - Ensembl, May 2017

[refGRCm38Ensembl-3] GRCm38: Ensembl release 89: ENSMUSG00000032796 - Ensembl, May 2017

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2591971-6] Nagayoshi T, Mattei MG, Passage E, Knowlton R, Chu ML, Uitto J. . Genomics. 1990-01, 5 (4): 932–5. PMID 2591971. doi:10.1016/0888-7543(89)90136-5.

[entrez-7] .

[pmid9006922-8] Utani, A; Nomizu M; Yamada Y. . J. Biol. Chem. (UNITED STATES). 1997-01, 272 (5): 2814–20. ISSN 0021-9258. PMID 9006922. doi:10.1074/jbc.272.5.2814.

[pmid10934193-9] Talts, J F; Sasaki T; Miosge N; G?0?2hring W; Mann K; Mayne R; Timpl R. . J. Biol. Chem. (UNITED STATES). 2000-11, 275 (45): 35192–9. ISSN 0021-9258. PMID 10934193. doi:10.1074/jbc.M003261200.