PRNP

PRNP（普里昂蛋白）為人類主要普里昂蛋白PrP的基因編碼，也稱之為CD230（分化簇230）[6][7][8][9]。該蛋白的主要表达于神經系統，但也會表达在人體其他組織[10][11][12]。

朊毒體蛋白
已知的結構 PDB 直系同源搜索: PDBe RCSB PDBID列表 1E1G、​1E1J、​1E1P、​1E1S、​1E1U、​1E1W、​1FKC、​1FO7、​1H0L、​1HJM、​1HJN、​1I4M、​1OEH、​1OEI、​1QLX、​1QLZ、​1QM0、​1QM1、​1QM2、​1QM3、​2IV4、​2IV5、​2IV6、​2K1D、​2KUN、​2LBG、​2LEJ、​2LFT、​2LSB、​2LV1、​2OL9、​2W9E、​3HAF、​3HAK、​3HEQ、​3HER、​3HES、​3HJ5、​3HJX、​3MD4、​3MD5、​3NHC、​3NHD、​3NVF、​4DGI、​4E1H、​4E1I,%%s1E1G、​1E1J、​1E1P、​1E1S、​1E1U、​1E1W、​1FKC、​1FO7、​1H0L、​1HJM、​1HJN、​1I4M、​1OEH、​1OEI、​1QLX、​1QLZ、​1QM0、​1QM1、​1QM2、​1QM3、​2IV4、​2IV5、​2IV6、​2K1D、​2KUN、​2LBG、​2LEJ、​2LFT、​2LSB、​2LV1、​2M8T、​2W9E、​3HAF、​3HAK、​3HEQ、​3HER、​3HES、​3HJ5、​3HJX、​3MD4、​3MD5、​3NHC、​3NVF、​4DGI、​4E1H、​4E1I、​4KML、​4N9O
識別號
别名	PRNP；, ASCR, AltPrP, CD230, CJD, GSS, KURU, PRIP, PrP, PrP27-30, PrP33-35C, PrPc, p27-30, prion protein
外部ID	OMIM：176640 MGI：97769 HomoloGene：7904 GeneCards：PRNP
相關疾病
傳染性海綿狀腦病、​克雅二氏病、​致死性家族失眠症、​Gerstmann–Sträussler–Scheinker症候群、​Huntington disease-like 1、​spongiform encephalopathy with neuropsychiatric features[1]
基因位置（人类） 染色体 20號染色體[2] 基因座 20p13 起始 4,686,350 bp[2] 终止 4,701,590 bp[2]
基因位置（小鼠） 染色体 小鼠2号染色体[3] 基因座 2 F2|2 64.07 cM 起始 131,909,928 bp[3] 终止 131,938,429 bp[3]
RNA表达模式
查阅更多表达数据
基因本體 分子功能 • chaperone binding • ion channel binding • microtubule binding • ATP-dependent protein binding • 金屬離子結合 • tubulin binding • 血浆蛋白结合 • 相同蛋白质结合 • copper ion binding • lamin binding • amyloid-beta binding • 蛋白酶結合 • glycosaminoglycan binding • type 5 metabotropic glutamate receptor binding • type 8 metabotropic glutamate receptor binding • signaling receptor activity • 大分子复合物结合 • cupric ion binding • cuprous ion binding 細胞組分 • mitochondrial outer membrane • 膜 • 線粒體 • integral component of membrane • 細胞質 • 高尔基体 • 细胞膜 • cell surface • 内质网 • 脂筏模型 • anchored component of membrane • 外排體 • 细胞核 • extrinsic component of membrane • 细胞质基质 • 突触后致密物质 • 包涵体 • 树突 • anchored component of external side of plasma membrane • 核膜 • 細胞內膜結合細胞器 • postsynapse 生物學過程 • negative regulation of protein phosphorylation • negative regulation of interferon-gamma production • response to cadmium ion • negative regulation of calcineurin-NFAT signaling cascade • response to copper ion • negative regulation of apoptotic process • response to oxidative stress • negative regulation of sequence-specific DNA binding transcription factor activity • negative regulation of T cell receptor signaling pathway • regulation of protein localization • negative regulation of activated T cell proliferation • cellular response to drug • cell cycle arrest • learning or memory • cellular copper ion homeostasis • cellular response to copper ion • 細胞週期 • 代谢 • negative regulation of interleukin-17 production • protein homooligomerization • negative regulation of interleukin-2 production • regulation of potassium ion transmembrane transport • 长期记忆 • positive regulation of cell death • negative regulation of protein processing • protein destabilization • activation of protein kinase activity • calcium-mediated signaling using intracellular calcium source • negative regulation of catalytic activity • positive regulation of neuron apoptotic process • regulation of peptidyl-tyrosine phosphorylation • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of protein tyrosine kinase activity • positive regulation of protein targeting to membrane • modulation of age-related behavioral decline • dendritic spine maintenance • negative regulation of long-term synaptic potentiation • regulation of glutamate receptor signaling pathway • positive regulation of neuron death • negative regulation of amyloid-beta formation • regulation of intracellular calcium activated chloride channel activity • negative regulation of dendritic spine maintenance • negative regulation of amyloid precursor protein catabolic process • positive regulation of protein localization to plasma membrane • response to amyloid-beta • cellular response to amyloid-beta • regulation of calcium ion import across plasma membrane • neuron projection maintenance Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	5621	19122
Ensembl	ENSG00000171867	ENSMUSG00000079037
UniProt	P04156	P04925
mRNA​序列	NM_183079 NM_000311 NM_001080121 NM_001080122 NM_001080123 NM_001271561	NM_001278256 NM_011170
蛋白序列	NP_000302 NP_001073590 NP_001073591 NP_001073592 NP_001258490 NP_898902 NP_000302.1 NP_001073590.1 NP_001073591.1 NP_001073592.1 NP_898902.1	NP_001265185 NP_035300
基因位置​（UCSC）	Chr 20: 4.69 – 4.7 Mb	Chr 2: 131.91 – 131.94 Mb
PubMed​查找	[4]	[5]
維基數據

參考文獻

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